Recombinant Tissue Factor (TF)

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A growth factor-like protein for tissue regeneration

• Found as membrane associated
  
• Recently found also as soluble (either encrypted in microvesicle or not)
  
• TF revised role in coagulation
  
• initiator
• thrombus growth

• Recent findings indicate that tissue factor has other roles besides (following) coagulation (wound healing)
• Angiogenesis
• TF KO mouse lethality due to failure in vascular dev.
• Tumor growth (angiogenesis)
• Cell Chemotaxis
• mAb anti-TF> reduced migration of fibroblast, monocyte
• Up-regulation of IL-8 (tumor metastasis)
• Inflammation
• Up-regulation of proinflammatory cytokines mRNA (FVIIa –TF)
• Arthritis development in joint of mice (sTF/LPS)